Diethylstilbestrol (DES) for Dogs: Incontinence & Prostate Treatment

Cushing’s disease is a condition that impacts dog adrenal glands. Visit Petco to learn the signs, causes, symptoms and treatment options of this disease. 

This article explains how a dog's sense of smell can influence behavior by means of pheromones.

Distemper is an extremely contagious & potentially lethal viral infection that can infect dogs and other animals. Learn how to protect your dog against distemper.

Search Petco for all the information you need on hip dysplasia in dogs. We want to help keep your pet happy and healthy with the treatment plans we can provide.

Learn about bladder stones in dogs and cats and help improve your pet's urinary system. Causes, symptoms, treatments & more.

Here are some of the most common hereditary and/or congenital health conditions found in dogs, along with additional information regarding symptoms, causes and treatment.

Do you have questions about pancreatitis in dogs? Petco has answers. Read to learn about dog pancreatitis causes, symptoms and & treatment options.

I am sorry to hear that you and waffles are dealing with kidney disease. But it sounds like you are on top of it and are being very proactive, which is great! It is ok to use diethylstilbestrol (i.e. DES or stilbestrol) with the Aventi supplement. These 2 should not cause problems when given together. I am not sure what stage waffle’s kidney disease is at, and I am not sure the nature of his urinary incontinence. But, I just wanted to mention that since kidney disease causes dogs to drink more and subsequently urinate a larger volume more frequently, his incontinece could potentially improve as his kidney disease is managed, making him less reliant on the DES down the line. There are Many things we use to help manage kidney disease depending on the stage of disease, the blood work values, the signs the dog is showing etc. Special veterinary diets such as Hills k/d diet or royal canin renal support diet can be very helpful as part of the management. I would ask waffle’s veterinarian if a specialized diet would make sense for him. If waffle begins showing any signs such as poor appetite or vomiting there are medications his vet can prescribe that will help a lot as well. Good luck with everything! And let us know if we can help further.

Rosa is a very young dog to develop urine incontinence. If DES has not been effective, it would be worth the check if there is other cause of leakage. In some rare cases dogs develop urine incontinence because of anatomical abnormalities they have been born with. For example, inappropriate position of the ureters. Your vet will have to do a few tests, like urinalysis, blood test to rule out kidney disease and diabetes and then, perform ultrasound and contrast x-ray of the urinary tract to rule in/out anatomical abnormalities.

I'm not sure if you mean that she is already on DES (low dose estrogen) when you say "HRT"[hormone replacement therapy]. If she is already on DES, adding the mediation Proin may help with her wetting herself at night.

I'm sorry to hear that Bijou has developed some leaking. Unfortunately we do see that in a number of spayed females. Proin is one of the most common medications that we will use for urinary incontinence, but there are several others that you can try as well. I am attaching a handout with more information about urinary incontinence including treatment options below. https://veterinarypartner.vin.com/default.aspx?pid=19239&id=4952092 I would recommend asking your veterinarian about trying another medication for incontinence. Incurin or DES are the next most common medications to try after Proin. Good luck! I hope that was helpful. Thanks for using PetCoach.

Poor Lulu! If she has been checked for underlying problems that could cause incontinence (such as diabetes, Cushing's disease, or chronic kidney disease), then I agree that it's likely her incontinence is due to being an older spayed female. I would recommend asking your veterinarian about medication to control this condition, such as Proin or DES (diethylstilbestrol) - these are quite effective at managing incontinence in most cases :)

Hi there. PPA (phenylpropanolamine, or Proin) is a very common first-line choice for urinary incontinence in female dogs, and often works well in my experience. So it's likely that this could be a good option for Sofi, depending on whether she has any other underlying health issues to consider. Unfortunately, we cannot provide a prescription over the internet, as legally this has to be done by a veterinarian who has physically examined your pet. So I would recommend making an appointment with a veterinarian in your area to bring Sofi in for an exam. He/she can discuss medication options for urinary incontinence with you, and should be able to provide a prescription for whatever medication the two of you decide to try.

It sounds as though Ruby may be developing an infection in the urinary tract as the cause for blood in the urine. This can be very common in dogs with urinary incontinence, even while on medication. I do not recommend stopping the Estradiol. However, Ruby does need to be examined by your veterinarian and have a urinalysis as soon as possible. If her urinalysis shows bacterial infection she will likely need a course of antibiotics and possibly a safe anti-inflammatory medication for pain.