My 4-year-old Spinone leaks urine at night, why isn't DES helping?

You are correct, Proin and DES are both medications that are commonly used to treat urinary incontinence in dogs. However, its possible that urinary tract infections, bladder stones, or bladder tumors could also cause these symptoms. Therefore, a visit to your vet for at least a urinalysis (urine test) is indicated. If no cause is found, then medication such as DES or Proin can be prescribed by your veterinarian. Antihistamines will have a significant effect on urination in dogs. If you feel that we haven't met your expectations, please contact customer service at customerservice@Petco Pet Education Center, formerly Petcoach.com. Thank you for using Petco Pet Education Center, formerly Petcoach!

It could be Willow is suffering from spay incontinence. Lack of estrogen may cause the urethral sphincter (a muscle used to control the exit of urine) to relax and release urine involuntarily. The good news is this can be treated medically if this is what is happening with her. I should have her seen by a vet for this problem. I hope this helps!

I'm sorry to hear that Bijou has developed some leaking. Unfortunately we do see that in a number of spayed females. Proin is one of the most common medications that we will use for urinary incontinence, but there are several others that you can try as well. I am attaching a handout with more information about urinary incontinence including treatment options below. https://veterinarypartner.vin.com/default.aspx?pid=19239&id=4952092 I would recommend asking your veterinarian about trying another medication for incontinence. Incurin or DES are the next most common medications to try after Proin. Good luck! I hope that was helpful. Thanks for using PetCoach.

Poor Lulu! If she has been checked for underlying problems that could cause incontinence (such as diabetes, Cushing's disease, or chronic kidney disease), then I agree that it's likely her incontinence is due to being an older spayed female. I would recommend asking your veterinarian about medication to control this condition, such as Proin or DES (diethylstilbestrol) - these are quite effective at managing incontinence in most cases :)

Hi there and thank you for using Pet Coach to address your concern. This sounds like urinary incontinence and that it is not secondary to a UTI. This could be caused by urethral sphincter mechanism incompetence (USMI), but is less likely to occur in males and more in females. JD could have a back problem or other neurological condition leading to decreased urethral closure pressure. I would recommend a trial of a medication called PPA or DES and see if the trial helps reduce the urinary incontinence. If there is no improvement after the trial, I would recommend more diagnostics such as abdominal ultrasound, x-rays or CT scan with contrast. I hope this helps guide you in the right direction. Please let me know if you have any other questions or concerns and I would be happy to help you further.

It could actually be spay incontinence. Lack of estrogen may cause the urethral sphincter (a muscle used to control the exit of urine) to relax and release urine involuntarily. This can be treated with medication. I'd have Coco seen by a vet for this issue.

The most likely fluid in a spayed female dog would be urine. When a dog dribbles urine or leaves spots of urine on the bedding I often think about urinary tract infections. Older dogs can also develop urinary sphyncter incompetence (or a weak sphyncter), making it difficult for them to hold their bladder overnight. There are also less common causes, for instance bladder stones or endocrine diseases. Your veterinarian will likely offer to run a urinalysis, a urine culture, and maybe some bloodwork on Sassy to determine what might be causing the urine leaking. There are antibiotics we use for urinary tract infections and if it appears to be loss of bladder control there are medications to help with that as well. A visit to the vet should help you sort out the cause and hopefully get Sassy acting more like herself. I hope this was helpful!