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How soon does Depo Provera in dogs prevent pregnancy or mating?

Updated on September 23, 2025

Pet's info: Dog | Canaan Dog | Female | unspayed | 11 months and 2 days old

Depo provera 150mg injection for female dogs how time it needs to work for preventing mating or pregnancy?

1 Answer

Most Helpful Answer

Destini R. Holloway, DVM

Answered By Destini R. Holloway, DVM

Veterinarian

Published on September 23, 2016

The Depo Provera (Medroxyprogesterone acetate) drug is effective immediately and can be used to regulate a pets reproductive cycle when given IM every 5 months. It has to be strictly monitored by your vet. Although I will say that most vets won't use this drug because it has some serious possible side effects including iatrogenic: Diabetes Mellitus, Hypothyroidism, and Pyometra. I myself won't use or recommend this drug in any of my patients. And besides paying the female, there are no alternative ways to prevent pregnancy in dogs that I am aware of at this time.
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