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My dog's eyes are bulging. Is it a side effect of his antibiotics?

Updated on September 23, 2025

Pet's info: Dog | Shih Tzu | Male | neutered | 8 years and 5 months old | 11 lbs

Oscar is on antibiotics for skin Staphylococcus infection for 4wks now - Rilexine also Chlorphenamine. He looks / seems a lot better and it's good to see that his eyes are open properly, but they seem to be getting wider and wider to the extent they look very bulged tonight !? Could this possibly be a side effect of the tablets ? - thank you - lisa

1 Answer

Most Helpful Answer

Rodrigo Roca, DVM

Answered By Rodrigo Roca, DVM

Veterinarian

Published on August 26, 2017

Hello, sorry to hear about Oscar. Rilexine is an antibiotic that generally can cause GI side effects including a decreased appetite, vomiting and diarrhea. Chlorphenamine can be contra-indicated in dogs that were previously diagnosed with narrow angle glaucoma, however the most common side effects also have to do with GI signs (vomiting, diarrhea, and anorexia). Other side effects include dry mouth, decreased urinations, and sedation.

On the picture Oscar appears to be holding his eye lids in an open and comfortable position. His left pupil appears normal size. The rest of the picture is a little blurry but I cannot see any obvious redness or discharge from his eyes.

I would monitor for any discharge, squinting, redness, or pain around his eyes and then consider bringing him to your veterinarian if you note any of the above. Otherwise, Shih-Tzu breeds tend to have eyes that are more prominent and bulging out compared to other breeds.

Hope this helps and best of luck.
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