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Updated on September 23, 2025
Pet's info: Cat | Siamese | Male | neutered | 11 years and 9 months old | 10 lbs
1. What does this statement mean – NB-fPLi test is relatively sensitive and specific for pancreatitis BUT this may be secondary to another underlying condition, e.g. hypovolemia? 2. Are biopsies of small intestine and live the definitive diagnosis of pancreatitis but not ultrasonography? 3. Can the underlying cause of pancreatitis be IBD/lymphoma? Should one always check for the underlying cause in order to apply the proper treatment?
3 Answers

Answered By Dr. Massimo Orioles, DVM, Cert AVP, MRCVS
Veterinarian
Published on August 23, 2017
Answered By Dr. Massimo Orioles, DVM, Cert AVP, MRCVS
Veterinarian
In order:
1. other causes can determine an increase levels in fPLI. It is said that fPLI is usually very sensitive (so it will increase its levels easily) but not so specific as, when increased, can be triggered by other causes (like gastrointestinal diseases for example) that must be ruled out.
1Pet Parents found this answer helpful
Answered By Dr. Massimo Orioles, DVM, Cert AVP, MRCVS
Veterinarian
2. Biopsies of pancreas can lead to definitive diagnosis. This is rarely performed though as usually the diagnosis is established with excellent confidence combining clinical signs, physical examination, blood tests and possibly ultrasound findings.
Pancreatitis can be secondary to other causes like IBD/lymphoma as they can trigger a generalized inflammatory reaction.
1Pet Parents found this answer helpful