Mirtazapine Cat Medicine | Petco

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Vet Q & A
My cat ate my antidepressant. She's drowsy. Is this an emergency?
Mirtazapine does have a side effect of drowsiness or sedation in pets. It is commonly used in cats as an appetite stimulant. 30mg would be 4 times higher than I normally use, and this overdosage can cause: 57% vocalizing, 38% agitated, 23% vomiting, 21% tachycardic, 15% ataxic and 11% lethargic. The symptoms can last a little longer than 72 hours. As long as Dolly is still eating and drinking normally, I would continue to watch her. If the she is still not completely normal in a day or two, she may need a checkup with a vet.
Updated on September 24th, 2025
Health & Wellness
Is Mirtazapine safe for cats with kidney disease and megacolon?
Mirtazipine can cause serotonin syndrome which is characterized by hyperactivity, muscle tremors, vocalization and behavior changes. This is more likely at high doses but has been reported to occur at typical doses as well. It is cleared through the kidneys so a dose reduction is typically recommended for cats with decreased kidney function. Megacolon should not be a concern.
Updated on September 24th, 2025
New Pet
My cat stopped Mirtazipine. Why is he sleepy and not eating now?
Mirtazipine usually only stays in their system for 24-72 hours dependent on how high the dose was. If he was being dosed daily it likely was a small dose and will only be effective for approximately 24-36 hours. I would talk to your vet about continuing it. If they haven’t figured it why he isn't eating, then they may recommend additional diagnostics like blood work or X-rays. If you already know then you can continue mirtazipine longer until he is feeling better. And yes, he may have developed a preference for the tuna juice. You can continue to add tha to his other food. I hope this helps.
Updated on September 24th, 2025
Health & Wellness
Is mirtazapine safe for my pet's blood pressure with amlodipine?
Mirtazapine is safe to use with amlodipine. Mirtazapine at high doses could potentially decrease blood pressure, but at typically prescribed doses, it is safe to give with amlodipine. Your vet may want to monitor blood pressure a few days after starting the mirtazapine just to be sure its all looking good. Thanks for asking Petco Pet Education Center, formerly Petcoach!
Updated on September 24th, 2025
Vet Q & A
My cat is sick and in pain. What can I give her for pain and appetite?
I would not give her morphine without seeing a vet as this can cause major respiratory depression and severe nausea. Also without seeing if she is healthy for morphine, it could make her get worse. The mirtazapine can be given for an appetite stimulant but cats can only tolerate 3.75mg (1/4 tablet of a 15mg mirtazapine) every 72 hours. If at all possible, I would strongly consider having a vet take a look at her to see if there is anything else they can do for her and to figure out why she isn't feeling well. I hope this helps.
Updated on September 24th, 2025