Training & BehaviorWhat's the safest anxiety medication for my cat: Fluoxetine or Amitriptyline?
Ultimately, this is a decision that really needs to be made by the prescribing veterinarian, as there may be good reasons for choosing one of these medications over the other for a particular patient. But in general, I can tell you that most veterinary behaviorists prefer SSRIs like fluoxetine over older TCAs like amytriptyline as a first-line choice for anxiety issues in cats because they tend to have fewer side effects and are better tolerated by most patients.
I personally use fluoxetine frequently in both dogs and cats, and have not prescribed amirtiptyline in years. But again, your vet may have good reasons for whichever medication they recommend - just ask, and express your concerns if you have any so that the two of you can come to the best decision for Fiona :)
Updated on September 24th, 2025