Not for use in dogs who are hypersensitive (allergic) to it.
Consult your veterinarian regarding heartworm testing your dog prior to and during use of this medication.
Use with caution in dogs with pre-existing epilepsy.
Not for use in Collies or other herding breeds over the recommended heartworm prevention dose unless under the strict supervision of a veterinarian. If your dog is one of these breeds and received a higher dose, observe your pet for at least 8 hours after giving the medication for weakness, staggering, fever, dilated pupils, trembling, or pressing the head against a wall. Contact your veterinarian immediately if you see these signs.
Do not use in puppies less than 8 weeks of age or less than 5 pounds.
Use with caution in breeding females. The safe use of milbemycin oxime plus spinosad in breeding males has not been evaluated.
Consult your veterinarian regarding physical examinations and heartworm testing your pet prior to, and during, treatment with Trifexis.
Properly dispose of unused medication, as it may be toxic to fish and other animals.