Spironolactone Tablets should be given orally as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. Wearing gloves is recommended when handling this medication, especially if you are pregnant. Wash your hands thoroughly with soap and water afterward (even if gloves are worn). Diuretic medications may increase the number of times your pet will need to urinate (especially at the start of treatment or when the dose is changed). Ensure your pet always has access to fresh, clean drinking water while taking this medication. If possible, try to give the prescribed dose(s) earlier in the day to help avoid nighttime urinary urgency. This medication is usually recommended to be given with food (or within 30 minutes after feeding). If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.