Description

Apoquel (oclacitinib tablet) for Dogs, 1 Prescribed Oral Medicine for Allergic Itch1: Apoquel is a revolutionary oral medicine for dogs with allergic itch. Apoquel can be used short-term or for long-term maintenance therapy2,3 in dogs 12 months of age and older. Stops Allergic Itch at the Source4: Apoquel is not a steroid, antihistamine, or cyclosporine (a type of drug that reduces immune system activity). Apoquel is in a different category of medications. Unlike other medicines, Apoquel blocks allergic itch at the source. So, it works at the underlying cause of itch to provide relief fast. Fast-Acting Allergy Itch Relief: If your dog is scratching, licking, or chewing like crazy, you want to provide fast, effective relief. Apoquel Tablets start relieving allergic itch within 4 hours5 and control it within 24 hours2.

• - The use of Apoquel has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporine. Available in Three Strengths: Apoquel Tablets come in 3.6 mg, 5.4 mg, and 16 mg based on your dog's body weight. Follow your veterinarian's instructions for dosing as prescribed. You can administer to your dog orally once a day with or without food. Apoquel is now available in a pork-liver flavored chewable. Apoquel Tablets control itching (pruritus) associated with allergic dermatitis and control atopic dermatitis in dogs at least 12 months of age. Apoquel has been prescribed for over 14 million dogs6 and is 1 in pet owner and vet satisfaction for oral medications for allergic itch in dogs.7,8 It goes right to the source to help stop itching and relieve associated inflammation in affected canines providing relief in as little as 4 hours.5 Apoquel is given twice daily for up to 14 days, and then given once daily for maintenance therapy
• - You can use for both short-term or long-term therapy in your dog and discontinue use without tapering. Since Apoquel is neither a steroid nor an antihistamine, your dog will avoid many of the unpleasant side effects that are often associated with these medications. In a 5-year safety review, the most common individual side effects reported with Apoquel were vomiting, diarrhea, lethargy, anorexia, and bloodwork changes.9 The most common reported side-effects occurred at a rate of less than one dog reacting out of 10,000 dogs treated.10 Apoquel Chewable (oclacitinib chewable tablet) is now available and is another easy-to-administer option if your dog is difficult to pill. Both Apoquel Tablet and Apoquel Chewable are available by prescription only. Talk to your veterinarian about which is best for your dog. IMPORTANT SAFETY INFORMATION: Do not use Apoquel in dogs less than 12 months of age or those with serious infections
• - Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines. See full Prescribing Information atApoquelPI.com. References: Vets, n250, Pet Owners, n491, 1. Data on file, PetTrak Total Unique Patient Count, December 2022, Zoetis Inc. (TI-09437), 2. Data on file: Study Report A161C-US-21-C02, Zoetis Inc., 2022 (TI-09898), 3
• - Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015,26(3):171-179, e35. doi:10.1111/vde.12194 (AR-01949), 4. Data on file: Study Report A461N-US-21-B66, Zoetis Inc. 2022, 5. FOI Apoquel Chewable FOI Summary: 2023/06/09 Original NADA 141-555 (v2.0). 6. Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL)is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Therapy. 2014,37(4)317-24. doi:10.1111/jvp.12101 (AR-00542), 7. Data on file, Apoquel Cytopoint Vet Tracker Wave 11 (December 20 2018) (TI-04447), 8. Data on file, APOQUEL/CYTOPOINT Pet Owner Tracker Wave 11, 2022, Zoetis Inc. (TI- 08418), 9. Data on file. A Five-Year Post-Approval Safety Review for Apoquel in the US (May 2013 to August 2018), Zoetis Inc (TI-04506), 10
• - Volume 6C Summary of the Product Characteristics: SPC European Commission, Brussels. 1 Vol. 6C. July 10, 2006, 1-11. (AR-08728), Please note: The images shown are for illustrative purposes only. Your pet's medication may be delivered in a Vetsource Pharmacy vial. Packaging may vary. Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer. For: Dogs (12 months of age and older). Active ingredient(s): Oclacitinib maleate. Drug class: Janus Kinase (JAK) inhibitor, Immunomodulator. Product flavoring: This product is an unflavored coated tablet formulation. For the flavored chewable tablet formulation, please see Apoquel Chewable for Dogs. Product strength and size: Apoquel tablets are scored and are available in four strengths, containing 3.6 mg, 5.4 mg, or 16 mg of oclacitinib per tablet. Please ensure the selected product and quantity are appropriate for your pet, as recommended by your veterinarian
• - For current availability, please refer to the product selection above. Usage: Apoquel should be administered as directed by your veterinarian. Wash your hands immediately after handling tablets. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. If a dose is missed: Administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give more medication than prescribed or two doses at once. If you have questions about your pet's prescribed dosing schedule (e.g., timing, interval), please contact your veterinarian. Manufacturer Directions for Use: Give Apoquel to your dog as directed by your veterinarian. Apoquel is given twice daily for up to 14 days of therapy and once daily thereafter for maintenance. Apoquel may be given orally with or without food. Additional information may be provided within the manufacturer's full Prescribing Information
• - Always follow the specific instructions provided by your veterinarian regarding your pet's care. Storage: Store in a cool, dry place at a controlled room temperature between 68 to 77F, with excursions between 59 to 104F. Keep this and all other medications in a secure location out of the reach of children and animals. Any remaining half-tablets should be stored in the original package and used for the next dose. Exposure to extreme temperatures, light, or moisture can affect the integrity and effectiveness of medications. Always store this medication properly (e.g., away from the bathroom, kitchen sink, or other damp places). Side effects: Apoquel is generally well tolerated. The most common side effects reported for this medication are vomiting, diarrhea, decreased appetite, and lethargy. These effects usually diminish over time. Other reported side effects include (but may not be limited to) elevated liver enzymes, dermatitis, seizures, and increased thirst