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Ranitidine is a histamine blocker used for ulcer treatment and prevention. Ranitidine is not longer available in the U.S. Ranitidine was withdrawn from the market due to the presence of NDMA (N-nitrosodimethylamine), a known carcinogen and that may also be hepatoxic. NDMA in ranitidine is likely due to manufacturing and levels increase with storage/shelf life based on over time and based on temperature in which ranitinidine products stored.
Stomach ulceration, esophageal ulceration, increasing food transit through the GI tract
Zantac
Dogs, cats, horses, cattle
Gastrointestinal
No
Safe to use in pregnant and lactating animals.
Vomiting, diarrhea, irregular heartbeat, muscle tremors, rapid breathing
Ranitidine is in a class of drugs called Histamine type-2 (H2) receptor antagonists. It is used to decrease the amount of stomach acid released. This aids in the treatment of ulcers that are present and helps prevent ulcer formation in dogs and cats. It is also used in the treatment of gastritis (inflammation of the stomach), esophagitis (inflammation of the esophagus), and gastric or esophageal reflux. It may also stimulate movement of food through the stomach and intestine. However, proton pump inhibitors (PPI), such as omeprazole (Prilosec), may be more effects. Side effects are uncommon with Rantidine.
Ranitidine is used for GI ulcers, gastritis and/or esophagitis, though proton-pump inhibitors (eg, omeprazole) may be superior
Ranitine, like famotidine (Pepcid), is a H2 receptor antagonist. This type of medicaiton inhibits baseline and meal-stimulated acid secretion making the environment in the stomach more alkaline. Ranitidine in particular also have promotility effects, which means is increases GI movement of food.
Dogs: 2 milligrams per kilogram of body weight given orally every 8 - 12 hours.
Cats: 3.5 milligrams per kilogram of body weight given orally twice daily.
Ferrets: 24 milligrams per kilogram of body weight given orally every 8 - 12 hours.
Horses: 6.6 - 10 milligrams per kilogram of body weight given orally every 8 hours.
Rabbits: 2 - 5 milligrams per kilogram of body weight given orally twice daily.
75, 150 and 300 milligram tablets available; 25 milligram/milliliter injectable form.
Tablets: Keep dry and away from direct sunlight.
Injectable: Store in a cool place away from direct sunlight.
Lack of appetite and gastric reflux should decrease when animals begin taking this medication. It can take several days to see the full effects. However, Clinical studies on the effect of ranitidine on gastric disorders in dogs and cats are lacking.
This medication is very safe, if a dose is missed another dose can be given immediately.
Overdose is rare.
May include:
Adverse effects are uncommon in animals with oral administration
*Do not use in patients with a known hypersensitivity.
None
Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.