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Pimobendan for Dogs & Cats: Congestive Heart Failure Treatment

Published on November 1, 2024
Updated on November 5, 2025
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Pimobendan increases the heart's ability to pump blood and is used to treat certain types of congestive heart failure in dogs and cats.

Summary

Used For:

Congestive heart failure secondary to dilated cardiomyopathy or mitral valve insufficiency

Brands:

Vetmedin

Species:

Dogs and cats

Other names:

Cardisure, Acardi

Drug type:

Cardiac

Prescription required:

Yes

Pregnancy and lactation:

Safety in pregnant or lactating animals has not been established.

Side effects:

GI upset, lethargy, arrhythmias, ataxia, syncope, pleural effusion

General description

Pimobendan is an inodilator used to treat dogs with congestive heart failure secondary to dilated cardiomyopathy or mitral valve insufficiency.

Uses

Used in the treatment of congestive heart failure.

How it works

Pimobendan works by inhibiting phosphodiesterase and also by increasing the sensitivity of the heart to calcium causing vasodilation and increased cardiac contractions.

Dosage

Dogs: 0.5 milligrams per kilogram by mouth total daily dose using a combination of whole or half tablets. The total daily dose should be divided into two portions that are not necessarily equal, and the portions should be given approximately 12 hours apart.

Cats: 0.25 milligrams per kilogram of body weight by mouth every 12 hours.

Forms

Pimobendan Chewable Tablets or Capsules: 1.25, 2.5, 5 and 10 milligrams

Storage information & handling

Tablets and Capsules: stored at room temperature protected from moisture and light.

What results can I expect?

Reduction in congestive heart failure for which the medication was prescribed.

Missed Dosage

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule.

Never give two doses at once.

Overdose / acute toxicity

Overdose is possible and the severity is dose dependent.

Side effects

May include:

  • Diarrhea
  • Decreased appetite
  • Lethargy
  • Increased risk for arrhythmias
  • Weakness/ataxia
  • Syncope
  • Pleural effusion

Contraindications

Do not use in pets with:

  • Known sensitivity
  • Hypertrophic cardiomyopathy
  • Aortic stenosis
  • Cardiac arrhythmias

Drug interactions

Consult your veterinarian before using pimobendan with any other medications, including vitamins and supplements.

Calcium channel blockers and beta blockers can decrease the inotropic effects of pimobendan.

Precaution

Only for use with clinical evidence of heart failure.

The safe use in dogs younger than 6 months of age with congenital heart defects has not been established.

Use cautiously in pets with diabetes mellitus or other serious metabolic diseases.

Sources

Plumb’s Veterinary Drug Handbook

VIN Veterinary Drug Handbook

Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.

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