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Phenylbutazone is a non-steroidal anti-inflammatory drug used to treat conditions that create inflammation in domestic species. Due to the availability of safer and more effective options, this medication is rarely used in dogs, cats, and other small animals.
Inflammation, osteoarthritis, soft tissue injury
Butazolidin, Phenylbute
Horses, cattle, pigs, rarely used in dogs, cats and other small animals
Bute
Anti-Inflammatory
Yes
Safety for use in pregnant and lactating animals has not been established.
GI upset, jaundice, weakness, rapid breathing or seizures
Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation of soft tissues, muscles and bones. Newer, safer medications are available for dogs; however, phenylbutazone may be recommend by a veterinarian in select cases. The manufacturer recommends monitoring for anemia, low platelet and white blood cell counts, and liver and kidney damage.
Inflammation, pain, osteoarthritis, soft tissue injury, other inflammatory conditions.
Phenylbutazone disrupts the production of inflammatory prostaglandins in the body.
Dogs: 14.7 milligrams per kilogram of body weight given orally every 8hours initially then titrate down to lowest effective dose.
100, 200, 400 milligram tablets and 1 gram tablets are available; 200 milligram/milliliter injectable solution.
Tablets: keep dry and away from sunlight.
Injectable solution must be kept refrigerated.
Phenylbutazone begins working to decrease pain and inflammation within 1-3 hours after the first dose.
If a dose is missed, continue the next dose at the scheduled time.
Overdose can cause severe gastrointestinal upset, seizures, and kidney or liver failure.
May include:
Do not use in patients with:
Phenylbutazone should not be used in combination with any other medication that is a steroid or a non-steroidal anti-inflammatory drug (NSAID).
This medication is no longer considered safe for small animals. Many other options are now available.
Use in horses is still common and well-tolerated by this species.
Saunders Handbook of Veterinary Drugs
Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.