Hydroxyzine for Dogs & Cats: Itch Relief for Atopic Dermatitis

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Thank you for using Petco Pet Education Center, formerly Petcoach! While hydroxyzine is an antihistamine commonly used for allergies and might cause mild sedation in dogs, it is unlikely to resolve Hunter’s separation anxiety. I recommend trying positive reinforcement, providing distractions, or even using calming supplements for dogs or a product known as a “thundershirt” prior to resorting to medications. You should consult with your vet regarding any medications you may want to give to Hunter to confirm that there will be no interactions with anything he is currently taking and that the dose is appropriate for his size.

Hydroxyzine and Diphenhydramine are both human anti-histamines commonly utilized in the vet field for allergies. Histamines do not directly affect the liver, but will certainly have indirect effects.

In general, antihistamines are not very effective in dogs for itching - so unfortunately, it doesn't surprise me that you aren't seeing much effect with Piriton. You could certainly talk to Lily's veterinarian about trying a different antihistamine such as hydroxizine or diphenhydramine, as some dogs may respond a bit better to a different drug.

Most OTC antihistamines can be used in dogs, however you should **never** give any medications to your dog without the advice of your veterinarian. Legally though, we cannot direct you to medicate your pet in the absence of a physical exam and a VCPR (veterinarian-client-patient-relationship). [Allergies](https://www.petcoach.co/dog/condition/canine-allergies) can be frustrating to diagnose since they can have multiple causes ([environmental](https://www.petcoach.co/article/food-allergies-vs-environmental-allergies-whats-the-difference), [food](https://www.petcoach.co/dog/condition/food-allergies), [flea bites](https://www.petcoach.co/dog/condition/flea-allergy), etc.). Schedule an appointment with your veterinarian. Discuss [food elimination trials](https://www.petcoach.co/article/food-trials-for-allergies-in-pets-what-to-expect) and [allergy testing](https://www.petcoach.co/article/allergy-testing-immunotherapy-in-dogs) and if antihistamine use is indicated, he or she can give you a proper dose, The medication may provide some relief but your task is to try to determine what your dog is allergic to and decrease or eliminate it.

Most OTC antihistamines can be used in dogs; however you should never give any medications to your dog without the advice of your veterinarian. Allergies can be frustrating to diagnose since they can have multiple causes (inhaled, food, contact). Schedule an appointment with your veterinarian. Discuss food elimination trials and allergy testing and if antihistamine use is indicated, he or she can give you a proper dose, The medication may provide some relief but your task is to try to determine what your dog is allergic to and decrease or eliminate it. Monitor her for side effects including lethargy and weakness, and if you see those signs, have her seen by a vet right away. Best of luck.

Thanks for using Petco Pet Education Center, formerly Petcoach! Excellent question. They are all about the same though their efficacy is a bit different. This is because while they have the same mechanism of action, their bioavailability meaning how much is used by the body when taken is different. Benadryl appears to be the most effective out of the three in my experience and that is the one I would recommend though in theory they all should work. Good luck and have a great day!

Do not give any medications to your pet without the advice of your veterinarian. Schedule an appointment with your veterinarian. Since your dog has hot spots, she is at risk for a skin infection and requires antibiotics. Your vet can also prescribe a short course of steroids to break the itch cycle then can dispense or recommend an antihistamine to prevent the itchiness from returning. Some antihistamines work better than others in different dogs, so you will need to find the one that works best. A pet approved colloidal oatmeal bath can soothe itchy skin. Use cool water and pat dry after to minimize the itch. Consider adding an essential fatty acid supplement (usually a fish oil) to her diet to promote healthy skin. EFAs may also decrease inflammation. Search www.pet360.com for fish oil supplements. If a diagnosis of allergies is made, your task is to try to determine what she is allergic to and decrease or eliminate it. Discuss food elimination trials, hydrolyzed diets and allergy testing with your vet.