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Erythropoietin: Anemia Treatment for Dogs & Cats with Kidney Disease

Published on September 10, 2024
Updated on November 5, 2025
Reviewed by Petco's Veterinarian Team

Erythropoietin is used to stimulate red blood cells to go into circulation.

Summary

Used For:

Anemia associated with kidney disease

Brands:

Epogen, Procrit

Species:

Dogs and cats

Other names:

EPO

Drug type:

Endocrine

Prescription required:

Yes

Pregnancy and lactation:

Safe use in pregnant or lactating animals has not been established.

Side effects:

Seizures, fever, joint soreness, mouth ulcers, pain at the injection site

General description

Erythropoietin is normally made by the kidneys to stimulate the production and release of red blood cells from the bone marrow. Epogen and Procrit are synthetic forms of erythropoietin.

Buy Erythropoietin now on Petco. A prescription from your veterinarian may be needed to purchase.

Uses

Erythropoietin is used to stimulate the production of red blood cells, especially in cases of anemia resulting from chronic kidney failure.

How it works

Erythropoietin is a hormone produced by the kidneys to stimulate red blood cell formation and release them in the body. When kidney disease is present, this hormone declines. Human erythropoietin can be given to mimic the effects and stimulate red blood cell production.

Dosage

Dogs and Cats: 100 units per kilogram subcutaneously three times weekly, then decrease to maintain hematocrit in desired range

Ferrets: 50-150 units per kilogram subcutaneously three times weekly, then decrease to maintain hematocrit in desired range

Rabbits and other Small Mammals: 50-150 units per kilogram subcutaneously every 2-3 days, then decrease to maintain hematocrit in desired range.

Forms

Available in a 200 units/milliliter injectable form.

Storage information & handling

Store away from light in a tightly sealed container.

What results can I expect?

Red blood cell levels should slowly begin to normalize when this medication is given; it can take several doses.

Missed Dosage

If a dose is missed, it should be given as soon as possible.

Overdose / acute toxicity

More severe side effects may be seen with an overdose.

Side effects

May include:

  • Seizures
  • Fever
  • Joint soreness
  • Mouth ulcers
  • Pain at the injection site

Contraindications

*Discontinue use if side effects are noted.

Drug interactions

No known drug interactions.

Precaution

Do not use in pregnant animals unless directed by your veterinarian.

Sources

Saunders Handbook of Veterinary Drugs

Manufacturer information: Amgen - Epogen

Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.

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