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Chlorpheniramine for Dogs & Cats: Itching, Allergies & Sedation
Type-1 antihistamine
Summary
Used For:
Pruritus (itching) and as a mild sedative
Brands:
Chlor-Trimeton
Species:
Dogs and cats
Other names:
Drug type:
Antihistamine
Prescription required:
Yes
Pregnancy and lactation:
No known risk during pregnancy, use with caution in nursing animals
Side effects:
Sedation, gastrointestinal upset, anticholinergic effects (dry mouth, urinary retention)
General description
Chlorpheniramine is a type-1 antihistamine used to treat pruritus (itching) associated with skin conditions such as atopic dermatitis. Chlorpheniramine can also be used as a mild sedative. All dog or cat use in the US is extra-label.
Uses
Antihistamine, mild sedative
How it works
Chlorpheniramine reduces itching by blocking the effects of histamine.
Dosage
Dogs: 0.2-0.5 milligrams per kilogram body weight by mouth every 8-12 hours.
Cats: 1-4 milligrams per cat by mouth every 8-12 hours.
The medication dosages listed represent the variation in dosing for all underlying medical conditions. Medications should only be administered to pets under the direct guidance of a veterinarian.
Forms
Chlorpheniramine tablets come in 2 and 4 milligram sizes. The extended release tablets and capsules come in 8, 12 and 16 milligram sizes. The oral syrup comes in 2 milligram per 5 milliliter concentration. The oral suspension comes in a 4 milligram per 5 milliliter concentration.
Storage information & handling
Chlorpheniramine should be stored at room temperature. The tablets and sustained-release tablets should be kept in tight containers. The oral solution should be stored in light-resistant containers.
What results can I expect?
Not all patients respond in a predictable manner to chlorpheniramine, some animals respond well to the drug and others have little response at all.
Missed Dosage
If a dose is missed, continue with the next dosage at the scheduled time.
Overdose / acute toxicity
Overdoses can cause excitement, seizures, lethargy, coma, anticholinergic effects and death. Consult your veterinarian immediately if you suspect your pet has received an overdose of chlorpheniramine.
Side effects
May include:
- Lethargy
- Gastrointestinal upset (vomiting, diarrhea, decreased or absent appetite)
- Sedation
- Dry mouth
- Urinary retention
Contraindications
*Do not use in pets with a previous sensitivity.
Drug interactions
Chlorpheniramine may counteract the anticoagulation effects of anticoagulants such as heparin and warfarin.
Chlorpheniramine given with MAOIs (monoamine oxidase inhibitors) may cause prolonged anticholinergic effects (dry mouth, urinary retention). Increased sedation can occur if chlorpheniramine is given with other central nervous system depressants.
Precaution
Chlorpheniramine should be used with caution in patients with narrow angle glaucoma, hypertension, gastrointestinal obstruction, urinary obstruction, hyperthyroidism and cardiovascular disease.
Sources
Plumb’s Veterinary Drug Handbook
Manufacturer information: Schering-Plough HealthCare Products, Inc.
Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.