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Cetirizine is an antihistamine medication most commonly used as an adjunctive treatment for itching associated with allergies. It is often used extra-label in veterinary medicine.
Itching associated with allergies, allergic reactions, blocking histamine release in mast cell tumor
Zyrtec®, Piriteze®
Cats, Dogs, Horses
Antihistamine
No
Likely safe for pregnant or lactating animals, but consult a veterinarian before use
Vomiting, hypersalivation (drooling), drowsiness
Cetirizine is a second generation antihistamine medication that blocks the release of histamine, which is a substance that causes inflammation, skin redness, and swelling, often leading to itching. For this reason, cetirizine is typically used as an adjunctive treatment in the management of itching associated with allergies, allergic reactions, and blocking histamine release due to mast cell tumors. It is often used extra-label in veterinary medicine.
Itching associated with allergies, allergic reactions, and blocking histamine release in mast cell tumors
Cetirizine works by blocking H1 (histamine) receptors and decreasing the histamine release from basophils (a type of white blood cell) in some species.
Dogs: 0.5-1 milligrams per kilogram of body weight by mouth once daily
Cats: 5 milligrams per cat by mouth once daily
Horses: 0.2-0.4 milligrams per kilogram of body weight by mouth every 12-24 hours
Cetirizine HCl coated and chewable tablets for oral use are available in 5 milligram & 10 milligram sizes. Cetirizine HCl liquid suspension for oral use is available in a 1 milligram per milliliter concentration.
Keep in the original package or a childproof container at room temperature, out of the reach of pets and children.
Improvement in itching associated with allergies, resolution of allergic reaction, and management of histamine release from mast cell tumor.
If a dose is missed, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and give the next dose at the regularly scheduled time. Do not give two doses at once.
If an overdose is known or suspected, seek veterinary attention immediately. Signs of an overdose may include hyperactivity, vomiting, lethargy, panting, pupil dilation, and an increased heart rate.
*Vomiting
*Hypersalivation (drooling)
*Drowsiness at higher doses
*Use with caution in patients with liver or kidney dysfunction
*Use with caution in patients with previous sensitivity
Medications that depress the central nervous system may interact with cetirizine. Discuss all medications and supplements with your veterinarian before administering any new medication.
Due to limited experience in veterinary medicine, caution should be exercised with use in patients with existing liver or kidney disease, and reduced dosages are recommended.
Plumb’s Veterinary Drug Handbook
Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.