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Buspirone for Dogs & Cats: Anxiety & Fear Behavior Disorders

Published on September 10, 2024
Updated on November 5, 2025
Reviewed by Petco's Veterinarian Team
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Anxiolytic drug used in the treatment of anxiety-related behavior disorders in cats and dogs.

Summary

Used For:

Buspirone is a medication that reduces anxiety

Brands:

BuSpar

Species:

Dogs and cats

Other names:

Drug type:

Anti-anxiety

Prescription required:

Yes

Pregnancy and lactation:

No known risk has been demonstrated during pregnancy, recommended to avoid while nursing

Side effects:

Uncommon, though increased activity and attention seeking

General description

Non-benzodiazepine anxiolytic drug used in the treatment of behavior disorders relating to fear/phobias in cats and dogs.

Uses

Treatment of behavior disorders relating to fear and anxiety, especially in social interactions, in cats and dogs. For inter-cat issues, buspirone may be more effective for victim or defensive cat than the aggressor (eg, staring, stalking, attacking). Fluoxetine is recommended over buspirone for first line treatment of urine spraying due to greater effectiveness.

How it works

Buspirone reduces anxiety in dogs and cats with certain behavior disorders without acting as a sedative.

Dosage

Dogs: 0.5-2 milligrams per kilogram of body weight by mouth every 8 to 12 hours. Some sources recommend maximum dosage limits of 10-15 milligrams per dog by mouth every 8-12 hours.

Cats: 0.5-1 milligram per kilogram of body weight by mouth every 12 hours.

The medication dosages listed represent the variation in dosing for all underlying medical conditions. Medications should only be administered to pets under the direct guidance of a veterinarian.

Forms

Buspirone tablets for oral use are supplied in 5, 7.5, 10, 15 and 30 milligram sizes.

Storage information & handling

Tablets should be kept at room temperature in tight, light-resistant containers.

What results can I expect?

Buspirone will help reduce anxiety due to fear/phobia related behavior disorders without causing sedation

Missed Dosage

If a dose is missed, continue with the next dosage at the scheduled time.

Overdose / acute toxicity

Overdoses may cause vomiting, dizziness, drowsiness, and constricted pupils. Contact your veterinarian if an overdose occurs.

Side effects

May include:

  • Gastrointestinal upset
  • Slow heart rate
  • Stereotypic behaviors

Contraindications

*Avoid use in pets with previous sensitivity.

Drug interactions

Always consult your veterinarian before giving your pet any medication, vitamin, or supplement due to the potential for drug interactions.

The use of buspirone with other central nervous system (CNS) depressants may cause increased CNS depression. The following may cause increased plasma levels of buspirone if given concurrently, which may increase risk of adverse effects occurring:

  • Diltiazem
  • Erythromycin
  • Grapefruit juice
  • Ketoconazole
  • Itraconazole
  • Verapamil

Concurrent administration of an SSRI, MAOI (eg, selegiline, amitraz), TCA (eg, amitriptyline, clomipramine), mirtazapine, tramadol, trazodone, and.or St. John’s wort may increase the risk of developing serotonin syndrome.

Precaution

Buspirone should be used with caution in animals with severe liver or kidney disease, and aggressive animals.

Sources

Plumb’s Veterinary Drug Handbook

Manufacturer information: Mylan Pharmaceuticals Inc.

Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.

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