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Budesonide: Manage Inflammatory Bowel Disease in Dogs & Cats

Published on September 10, 2024
Updated on November 5, 2025
Reviewed by Petco's Veterinarian Team

Budesonide is a glucocorticoid used in the treatment of inflammatory intestinal diseases in dogs and cats.

Summary

Used For:

Inflammatory intestinal diseases

Brands:

Entocort EC, Uceris

Species:

Dogs and cats

Other names:

Drug type:

Immuno-suppressive

Prescription required:

No

Pregnancy and lactation:

Not safe for use in pregnant or lactating animals.

Side effects:

Increased thirst/urination, increased appetite, decreased activity, muscle weakness, panting

General description

Budesonide is a glucocorticoid with limited systemic effects. It is most often used in dogs and cats that are not responding to or are intolerant of systemic steroids.

Uses

Budesonide is used in the treatment of inflammatory intestinal diseases.

How it works

Budesonide has excellent topical activity. By delaying dissolution of the capsule until it reaches the duodenum (a part of the intestines), the drug can exert its topical anti-inflammatory effects in the intestines.

Dosage

Dogs: 1-3 milligrams by mouth every 24 hours.

Cats: 1 milligram by mouth every 24 hours.

The medication dosages listed represent the variation in dosing for all underlying medical conditions. Medications should only be administered to pets under the direct guidance of a veterinarian.

Forms

Budesonide extended-release capsules for oral use come in 3 and 9 milligrams. Budesonide may need to be compounded into dosage strengths that are suitable for cats and dogs.

Storage information & handling

Budesonide oral capsules should be stored at room temperature (59-86 degrees Fahrenheit).

What results can I expect?

Pet parents can expect an improvement in their pet’s intestinal inflammatory disease.

Missed Dosage

If a dose is missed, continue with the next dose at the scheduled time.

Overdose / acute toxicity

Overdoses are rare and usually are not of concern. In cases of massive overdose, decontamination is recommended.

Side effects

Budesonide can cause:

  • Increased thirst
  • Increased urination
  • Increased appetite
  • Decreased activity
  • Muscle weakness
  • Increased panting
  • Changes in the skin and hair coat
  • Weight gain
  • A pot-bellied appearance

Contraindications

*Avoid use in pets with a previous sensitivity to budesonide

Drug interactions

Drugs that inhibit the CYP3A enzyme can increase the amount of budesonide that enters the circulation.

Examples include:

  • Erythromycin
  • Cimetidine
  • Ketoconazole
  • Itraconazole
  • Fluconazole
  • Diltiazem

Oral antacids should not be given at the same time as budesonide; they may affect the pH of the stomach and dissolution of the drug’s coating is pH dependent.

Precaution

Budesonide should be used with caution in animals with gastrointestinal ulcers, active infections, diabetes mellitus or cataracts.

Sources

Plumb’s Veterinary Drug Handbook

Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.

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