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Aminoglycoside injectable antibiotic used to treat serious infections in dogs, cats, and other animals.
Urogenital infections, respiratory infections, skin infections, soft tissue infections, and others
Amiglyde-V, Amikacin C, Amikacin K-9, Amiject D
Dogs, cats, horses, cattle, birds, small mammals and reptiles
Antibiotic
Yes
Not safe for use in pregnant and lactating animals.
May see vomiting, kidney damage, hearing loss, or vestibular (balance) disorders.
Amikacin is an injectable aminoglycoside antibacterial used to treat aerobic gram-negative bacterial infections not responsive to more commonly used antibiotics. It is typically used in veterinary medicine to treat serious respiratory, urogenital, skin, and soft tissue infections.
Bacterial infections including urinary tract infections, respiratory tract infections, skin infections, soft tissue infections, and uterine infections.
Amikacin is a bactericidal antibiotic that stops bacterial growth by inhibiting protein synthesis in susceptible bacteria.
Dogs: 5 – 30 milligrams per kilogram of body weight intramuscularly, intravenously, or subcutaneously every 8 - 24 hours
Cats: 10 – 15 milligrams per kilogram of body weight intramuscularly, intravenously, or subcutaneously every 8 - 24 hours
Horses: 6 – 25 milligrams per kilogram of body weight intramuscularly or intravenously every 8 - 24 hours
Cattle: 12 milligrams per kilogram of body weight intramuscularly every 12 hours
Rodents/Small Mammals: 2.5 – 5 milligrams per kilogram of body weight intramuscularly or subcutaneously every 8 - 24 hours
Birds: 5 – 20 milligrams per kilogram of body weight intramuscularly every 8 - 24 hours.
Reptiles: 2.5 – 5 milligrams per kilogram intramuscularly every 24 – 72 hours.
50 milligrams per milliliter and 250 milligrams per milliliter amikacin solution for injection.
Store at room temperature.
Assuming that the infection being treated is susceptible to amikacin, resolution of the infection should occur during the treatment period.
Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule.
Never give two doses at once.
Early signs of toxicity include loss of balance and vomiting. May see symptoms of kidney disease including increase or decrease in drinking, lack of appetite, vomiting, depression, coma, and death.
May include:
Do not use in pregnant or lactating animals or in pets with:
Amikacin should be used cautiously with other drugs that may cause hearing loss, vestibular disease, or kidney disease. These include:
General anesthesia and neuromuscular blocking agents may also interact with amikacin.
Young and old pets are at increased risk of side effects.
Cats are very sensitive to the vestibular effects of aminoglycosides.
Do not use in animals who require their hearing to perform their work due to the risk of permanent hearing loss or vestibular impairment.
A culture and sensitivity test should be performed to verify the need for amikacin due to the seriousness of potential side effects.
Baseline bloodwork and urinalysis (to specifically identify casts) should be obtained prior to using this medication and should be repeated during treatment to monitor kidney function.
Plumb’s Veterinary Drug Handbook
VIN Veterinary Drug Handbook
Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.