My sick bull mastiff has bad blood test results. What's next?

Hello, I am sorry to hear about Daisy. Based on the blood work abnormalities it is possible that Daisy has an infection secondary to tick borne disease or another organism. Many of these diseases cause destruction of the platelets. The white blood cells are part of the immune system and fight infection. It is possible that this value went up despite being on treatment secondary to fighting a severe infection. However, if Daisy is still not feeling well or these counts don’t improve it may be possible that Daisy’s platelets are low due to a different cause such as immune mediated disease. Your veterinarian can help assess for this kind of disease and determine if treatment is needed if Daisy’s blood counts do not improve or she is clinically ill. Hope this helps, good luck!

The most striking abnormality is the low platelet count which can lead to spontaneous bleeding. Immunomediated thrombocytopenia is possible at this stage and more tests are needed to know if it is primary or secondary. Transfusion of blood products or whole blood may be considered. I would recommend to take her back immediately to your local veterinarian and discuss further investigations.

The problem here is to establish the underlying cause of thrombocytopenia (low platelets). Immune-mediated thrombocytopenia is one of the most common causes. This process usually occurs in the spleen although the liver also plays a role. Thrombocytopenia develops as platelet destruction exceeds compensatory production by the bone marrow. Immune-mediated thrombocytopenia can be classified as primary or secondary. Secondary processes can be caused by infective diseases or tumors very commonly. Usually to determine a diagnosis more tests needs to be performed like abdominal ultrasound and chest x rays. Infective diseases like Ehrlichia, Anaplasma spp for example should be ideally evaluated as well. Hope this answer was helpful, but please do not hesitate to contact us again on the forum (where you can post pics of the blood tests) or by requesting a consultation if you have any more questions or to discuss it any further.

Meddy likely is suffering from an infection (elevated white blood cell count). However without a clinical history, signs of apparent illness and for how long the condition has been active, there is no way to pinpoint where the infection is, and a cause. We do not just treat on account of blood test results Her liver parameters are borderline high, so that may or may not be significant or a sign of disease. Anotheer problem may be that this blood was examined in a lab for human medicine and therefore the parameter normals may just be different. Best consult with your veterinary doctor who has given Meddy an exam.

I'm sorry Meddy is sick. I am trying to understand exactly what is going on with him. It sounds like your vet is suspicious of an immune mediated disease (where Meddy's own immune system is malfunctioning and destroying her platelets (as well as possibly her red blood cells and/or white blood cells). A blood transfusion may have been required help Meddy survive. Let me briefly review the medications you've listed: *Zip vit- I am not familiar with this, but it seems to be a vitamin supplement. *I suppose "sucroll" may be the drug sucralfate, which is a medication that helps to decrease bleeding in the stomach and intestine. *Livotas is not something used in the US and I cannot find any information on it. *Thrombup is an herbal that may be beneficial when platelets are low (I don't have any experience with this one, and it is not generally used in the US) *Lisybin is a supplement for liver health. *Alamin R Forte is not something I have experience with but appears to be used for a number of different indications in India. *I assume Doxypet is doxycycline, which is an antibiotic commonly used to treat possible underlying infection that results in immune mediated cell destruction. Doxycycline also has some anti-inflammatory properties that can be helpful. *udiliv300 is ursodiol, which helps with bile flow from the gallbladder and through the liver *Venol is not a drug used in dogs in the US, so I am not sure what the purpose of this mediation would be for Meddy. *azathioprine suppressed the immune system and helps treat immune mediated diseases. Azathioprine can have negative side effects on the liver, so the liver protective medications listed may be to help try to minimize these negative effects on the liver. * I do not know what you mean by NS DNA D10. Regarding the pictures you've attached : The first picture is shows small spots of bleeding under the skin, which would commonly be seen with low platelet counts. The second picture looks like what is an amino acid supplement that can be given as an injection. I am not sure of the purpose of this medication for Meddy, but I don't see a reason it would cause harm. The third picture of the lab findings- shows the red cell count a little low (mild anemia), and there is no number for either the platelets or the total white blood cell count. Generally that means those counts are very low--too low for the machine to read. To try to answer your questions: I am not highly suspicious that this is liver cancer, but it is possible. We can see immune mediated cell destruction AS A CONSEQUENCE of cancer, so it may be that liver cancer, or another type of cancer, is the underlying cause. It is possible that the liver value abnormalities on the lab work are a side effect from the medication. You can talk to your vet about potentially having an abdominal ultrasound (sonogram of the belly) performed. This may help identify a tumor in the liver or elsewhere that may be the underlying cause of disease. The picture that you took with the spots on the skin-- this would be seen from low platelets. I suspect that the medications were all started BECAUSE of low platelets. It takes time to get that platelet count up, so bleeding will continue while platelets are low. So more bleeding will occur until the meds are working. I do not think that this is reaction to medications. (Having said that, unfortunately sometimes patients just do not respond well to treatment and we cannot get the platelet count up despite our best efforts). Regarding the jaundice that you've seen after the medication was given-- again I doubt this was a result of the medication. If his red blood cells are being destroyed by his immune system, this will result in jaundice. Additionally, following transfusion (even from a known blood source) jaundice is common. I hope that information helps, I can try to help more with a consult. Thank you for asking Petco Pet Education Center, formerly Petcoach!

Hi, Oscar needs to be hospitalized and treated with IV fluids, antibiotics, and gastrointestinal protectants. Additionally, he should be tested for infectious diseases such as leptospirosis and ultrasounded to determine if he has any problems in his liver or kidneys.

Hello. Those blood results indicate that there is a low red cell count, low white cell count and low platelets. This COULD indicate leukemia as all three cell lines are low, however it could also be due to a systemic infection and the platelets being low could be due to clumping. The first next step would be to send the blood away to an external lab to look for regeneration, as well as platelet clumps. If your dog is acting sick your vet may want to start on antibiotics in case of a systemtic infection. I suggest you go back to your vet and discuss these results, and discuss what the pathologist comments were if the blood was sent away externally. If bone marrow disease is suspected they can do a bone marrow biopsy.