Simparica Trio has been approved for dogs as young as 8 weeks and weighing as little as 2.8 lbs. However, it hasn’t been evaluated in pregnant and lactating dogs. It should also be used with caution in dogs who have seizures because the ingredient sarolaner has been associated with seizures, ataxia and tremors.
Most dogs won’t experience side effects. However, the most common were vomiting and diarrhea. In addition, before prescribing Simparica Trio, your veterinarian will perform a test to ensure your pup is heartworm negative because giving heartworm medicine to a dog that is already infected can be fatal. Consult your veterinarian if you think your dog is experiencing side effects and for general advice.